The car rental offices are located close to the parking lot, and in front of the main exit gate of Santiago Marino International Airport.
Some of the car rental agencies are:
Aco http://www.aco.com.ve/ Tel: 0295 269 12 70 0-800-7368226
Budget http://www.budget.com.ve/ Tel: 0295 400 81 38
Excellency Tel: 0295 262 29 55
Hertz Te:l 0295 267 16 59
Margarita Rentals Tel: 0295 269 12 85
In order to rent a car, you need to be at least 18 years old, have a valid driving licence, passport or valid ID, and a credit card. Every car is insured, and you will have to leave a deposit that will be reimbursed once you return the car.
It is possible that you may find Venezuelans' style of driving somewhat particular to begin with, but you will get used to after few hours of driving. It is always important to practice defensive driving.